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Blog polymorph

  1. CSD-Materials in action - reducing risk in solid form selection of APIs

    Elna Pidcock – Tue, 16 Feb 2021 13:51:00 GMT

    Here we summarise a publication from our collaboration with Pfizer, which demonstrates the use of the healthcheck methodology to reduce risk and select the most stable form across three different APIs.

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  2. CSD in action: analysis of the metastable polymorph of Loratadine

    Suzanna Ward – Tue, 16 Feb 2021 12:49:00 GMT

    Here we spotlight a recent publication which shows how CSD data supported a team from Novartis and NanoMEGA to analyse a metastable form of the antihistamine drug Loratadine. Part of our series highlighting examples of our data and software in use around the world.

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  3. Paper Spotlight; Structural Rugosity in Crystallisation

    Jason Cole – Fri, 11 Sep 2020 14:00:00 GMT

    The field of Crystal Structure Prediction (CSP) has grown dramatically over the last few decades, but today I want to highlight a recent paper which takes a new approach. The recent publication from Montis et al makes use of new informatics tools to assess surface roughness (rugosity) and proposes a relationship between this and ease of crystallisation. 

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