Thank you for contacting us about the licencing for using the CSD Python API on the cloud.
The main issue with use of our software on the cloud is that with instances being spun up and then destroyed, the licensing details will likely change each time a new instance is used.
We'd therefore recommend using the command line utility batch_register each time a new instance is spun up to ensure that the software is registered for that instance. (see https://www.ccdc.cam.ac.uk/support-and-resources/support/case/?caseid=c9c53a6b-e7e6-e611-8591-005056868fc8 for general instructions on its use)
Otherwise, as long as you have an unlimited licence you should be good to go.