• CSD Annual Statistics Now Available!

    Did you know that every year we generate a range of annual statistics based on the Cambridge Structural Database (CSD)?  These allow us to see how the CSD is evolving and provide some insights into the direction small molecule structural chemistry is headed.

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  • Supersized Aromatic Me

    ​I recently came across a report about the largest known aromatic molecule, to date,1 and it got me thinking about similar entries in the CSD. I know from editing structures into the database that a significant proportion of new entries contain an aromatic system. The structures also seem to be getting bigger and bigger but I had never really connected these two features in any detail. First of all, I was delighted to learn that the supersized structures from the report were already in the CSD.  Our new automated systems could deal with them without a problem and one of my colleagues had already cast their expert eye over them. In the report Dongho Kim and co-workers synthesised a [50]dodecaphyrin (KUHHIG, see below), the full name of which is in our curated entry but would have taken up half this blog so I decided not to include it! If you are wondering how to make your own supersized aromatic then the structure was synthesised to contain Hückel aromaticity by oxidising a non-aromatic [52]dodecaphyrin with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). Dongho Kim and co-workers appear to be record breakers in the world of these structures; the largest known aromatic prior to this was a [46]decaphyrin palladium(II) complex (DONZEN), also synthesised by the same research groups.2

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