BAGIM/SAGIM and CCDC webinar: Shubham Sharma — Integrating Experiments, Energetics, and Structural Informatics
Wednesday 15th January 2025, 10am PT / 1pm ET / 6pm BT
A critical milestone in the development of a commercial drug product is the selection of the optimum solid form for the active pharmaceutical ingredient (API).
Recently, the experimental methods to explore the solid form landscape have been supplemented by computational methods based on relative energies & structural informatics. In particular, the informatics-based assessment, dubbed as a “Health Check”, is a digital risk assessment that leverages a database of crystal structures to assign risk to the targeted solid form by comparing structural aspects of the target structure to database-derived knowledge.
In this webinar, Shubham Sharma from Pfizer will describe the use of these approaches to analyze four competing polymorphs of an MPO inhibitor.
Run by BAGIM (the Boston Area Group for Informatics and Modelling) and SAGIM (the Southern California Area Group for Informatics and Modelling) and sponsored by The CCDC (Cambridge Crystallographic Data Centre).